Sugar addiction: An Achilles' heel of auto-immune diseases?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35385700.
- Also identified by DOI 10.1016/j.cmet.2022.03.007.
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Abstract
In this issue of Cell Metabolism, Hochrein et al. identify a metabolic checkpoint controlling the transcriptional programming of effector CD4<sup>+</sup> T cells. The authors show that GLUT3-mediated glucose import and ACLY-dependent acetyl-CoA generation control histone acetylation and, hence, the epigenetic imprinting of effector gene expression in differentiated effector CD4<sup>+</sup> T cells. These findings suggest a novel therapeutic target for inflammation-associated diseases.
Medical subject headings
- ATP Citrate (pro-S)-Lyase
- Immune System Diseases