Antibiofilm and immunomodulatory resorbable nanofibrous filing for dental pulp regenerative procedures.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35386316.
- Also identified by DOI 10.1016/j.bioactmat.2022.01.027 and PMC identifier 8965695.
- Licence recorded as CC BY-NC-ND.
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Abstract
Multifunctional scaffolds with host defense peptides designed for regenerative endodontics are desirable nanobiotechnological tools for dentistry. Here, different scaffolds were tested for use during the pulp revascularization process, including poly(vinyl alcohol)-PVA hydrogels or resins, collagen hydrogels and poly(vinyl alcohol) PVA/Chitosan (PVA/CS) nanofibers. Based on time to degradation (21 days), nanofibers were chosen to be incorporated with ciprofloxacin and IDR-1002 (each at 50 mg/g). Nanofibers containing ciprofloxacin and IDR-1002 had anti-biofilm activity against <i>Enterococcus faecalis, Staphylococcus aureus</i> and a multispecies oral biofilm, besides anti-inflammatory activities. The <i>in vivo</i> subcutaneous tissue response to tooth fragments filled with nanofibers demonstrated a pulp-like tissue formation, when compared to empty teeth fragments. Thus, we designed a strong antimicrobial, immunomodulatory and regenerative candidate for pulp revascularization and regeneration procedures.