A Mg<sup>2+</sup>/polydopamine composite hydrogel for the acceleration of infected wound healing.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35386343.
- Also identified by DOI 10.1016/j.bioactmat.2021.11.036 and PMC identifier 8940763.
- Licence recorded as CC BY-NC-ND.
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Abstract
Bacterial infection is a vital factor to delay the wound healing process. The antibiotics abuse leads to drug resistance of some pathogenic bacteria. Non-antibiotic-dependent multifunctional biomaterials with accelerated wound healing performance are urgently desired. Herein, we reported a composite antibacterial hydrogel PDA-PAM/Mg<sup>2+</sup> that shows excellent self-healing and tissue adhesive property, and photothermal antibacterial functions for accelerating wound healing. The gel was composed of polyacrylamide (PAM), polydopamine (PDA), and magnesium (Mg<sup>2+</sup>) and prepared <i>via</i> a two-step procedure: an alkali-induced dopamine pre-polymerization and followed radical polymerization process. The composite gel shows excellent tissue adhesiveness and Mg<sup>2+</sup>-synergized photothermal antibacterial activity, inducing a survival rate of 5.29% for <i>S. aureus</i> and 7.06% for <i>E. coli</i> after near infrared light irradiation. The composite hydrogel further demonstrated efficient bacteria inhibition, enhanced wound healing and collagen deposition in a full-thickness skin defect rat model. Together, the PDA-PAM/Mg<sup>2+</sup> hydrogel presents an excellent wound dressing with excellent tissue adhesion, wound healing, and antibacterial functions.