c-Maf: The magic wand that turns on LSEC fate.
editorial · Level V
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- Record sourced from PubMed, PMID 35395181.
- Also identified by DOI 10.1016/j.stem.2022.03.011.
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Abstract
In this issue of Cell Stem Cell, Gómez-Salinero et al. (2022) identify c-Maf as a driver for murine liver sinusoidal endothelial cell (LSEC) fate and function during liver development, homeostasis, and repair. Similarly, c-Maf defines human LSECs, and its overexpression specializes generic HUVECs into functional induced-LSECs, potentiating regenerative therapeutics.
Medical subject headings
- Endothelial Cells
- Liver
- Proto-Oncogene Proteins c-maf