MDS/AML with del5q: An acquired "laminopathy"?
editorial · Level V
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- Record sourced from PubMed, PMID 35395184.
- Also identified by DOI 10.1016/j.stem.2022.03.008 and PMC identifier 10294253.
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Abstract
In this issue of Cell Stem Cell, Reilly et al. propose loss of LMNB1, the gene encoding lamin B1, often deleted in MDS/AML, as a novel genetic basis for the abnormal nuclear shape of neutrophils (known as acquired Pelger-Huët anomaly) and a cause of HSPC fate alterations promoting malignancy.
Medical subject headings
- Leukemia, Myeloid, Acute
- Pelger-Huet Anomaly