Comparative Effectiveness of mRNA and Inactivated Whole-Virus Vaccines Against Coronavirus Disease 2019 Infection and Severe Disease in Singapore.

Premikha, M; Chiew, Calvin J; Wei, Wycliffe E; Leo, Yee Sin; Ong, Benjamin; Lye, David Chien; Lee, Vernon J; Tan, Kelvin Bryan · Clin Infect Dis · 2022

retrospective_cohort · Level III

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Abstract

Compared with individuals vaccinated with Pfizer-BioNTech/Comirnaty, recipients of Sinovac-CoronaVac and Sinopharm were 2.37 (95% CI, 2.29-2.46) and 1.62 (95% CI, 1.43-1.85) times more likely to be infected with coronavirus disease 19, respectively, while individuals vaccinated with Moderna were 0.42 (95% CI, 0.25-0.70) times less likely to develop severe disease.

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