Intraoperative High Fraction of Inspiratory Oxygen is Independently Associated with Worse Outcome After Living-Donor Liver Transplantation: A Retrospective Study.

Abstract

Ischemia and reperfusion injury is an important factor that determines graft function after liver transplantation, and oxygen plays a crucial role in this process. However, the relationship between the intraoperative high fraction of inspiratory oxygen (FiO₂) and living-donor-liver-transplantation (LDLT) outcome remains unclear. A total of 199 primary adult-to-adult LDLT cases in Kyoto University Hospital between January 2010 and December 2017 were enrolled in this study. The intraoperative FiO₂ was averaged using the total amount of intraoperative oxygen and air and defined as the calculated FiO₂ (cFiO₂). The cutoff value of cFiO₂ was set at 0.5. Between the cFiO₂ <0.5 (n = 156) and ≥0.5 group (n = 43), preoperative recipients' background, donor factors, and intraoperative parameters were almost comparable. Postoperatively, the cFiO₂ ≥0.5 group showed a higher early allograft dysfunction (EAD) rate (P = 0.049) and worse overall graft survival (P = 0.036) than the cFiO₂ <0.5 group. Although the cFiO₂ ≥0.5 was not an independent risk factor for EAD in multivariable analysis (OR 2.038, 95%CI 0.992-4.186, P = 0.053), it was an independent risk factor for overall graft survival after LDLT (HR 1.897, 95%CI 1.007-3.432, P = 0.048). The results of this study suggest that intraoperative high FiO₂ may be associated with worse graft survival after LDLT. Avoiding higher intraoperative FiO₂ may be beneficial for LDLT recipients.