Evaluating human genetic support for hypothesized metabolic disease genes.

Dornbos, Peter; Singh, Preeti; Jang, Dong-Keun; Mahajan, Anubha; Biddinger, Sudha B; Rotter, Jerome I; McCarthy, Mark I; Flannick, Jason · Cell Metab · 2022

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Abstract

We investigate the extent to which human genetic data are incorporated into studies that hypothesize novel links between genes and metabolic disease. To lower the barriers to using genetic data, we present an approach to enable researchers to evaluate human genetic support for experimentally determined hypotheses.

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