How does maternal age affect genomic stability in the offspring?
Where this comes from
- Record sourced from PubMed, PMID 35426971.
- Also identified by DOI 10.1111/acel.13612 and PMC identifier 9124297.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In high-income countries, women tend to give birth at increasingly advanced ages. Despite its physiological, developmental, and medical consequences, why this tendency significantly affects genetic stability of the offspring remains largely unresolved. Accumulating evidence indicates that the higher the age of the mother at fertilization, the more intense the activity of transposable elements causing insertional mutations in functional DNA stretches in her oocyte involved in zygote formation.
Medical subject headings
- DNA Methylation
- Epigenesis, Genetic