Flying under the radar: TMEM106B(120-254) fibrils break out in diverse neurodegenerative disorders.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35427496.
- Also identified by DOI 10.1016/j.cell.2022.03.032 and PMC identifier 10154121.
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Abstract
Neurodegenerative diseases commonly exhibit aggregation of specific proteins that define each disease. Chang et al. (2022) establish that a C-terminal fragment of TMEM106B, a frontotemporal-lobar-degeneration risk factor, unexpectedly forms amyloid fibrils with similar structures in diverse neurodegenerative disorders. These unanticipated TMEM106B(120-254) fibrils may herald etiological shifts for several neurodegenerative diseases.
Medical subject headings
- Frontotemporal Dementia
- Frontotemporal Lobar Degeneration