SnapShot: Regulation and biology of PGC-1α.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35427500.
- Also identified by DOI 10.1016/j.cell.2022.03.027.
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Abstract
The peroxisome proliferator-activated receptor γ coactivator-1α (Ppargc1a) gene encodes several PGC-1α isoforms that regulate mitochondrial bioenergetics and cellular adaptive processes. Expressing specific PGC-1α isoforms in mice can confer protection in different disease models. This SnapShot summarizes how regulation of Ppargc1a transcription, splicing, translation, protein stability, and activity underlies its multifaceted functions. To view this SnapShot, open or download the PDF.
Medical subject headings
- Gene Expression Regulation
- Mitochondria