Infiltrative growth pattern of prostate cancer is associated with lower uptake on PSMA PET and reduced diffusion restriction on mpMRI.

Abstract

Recently, a significant association was shown between novel growth patterns on histopathology of prostate cancer (PCa) and prostate-specific membrane antigen (PSMA) uptake on [⁶⁸Ga]PSMA-PET. It is the aim of this study to evaluate the association between these growth patterns and ADC (mm²/1000 s) values in comparison to [⁶⁸Ga]PSMA uptake on PET/MRI. We retrospectively evaluated patients who underwent [⁶⁸Ga]PSMA PET/MRI for staging or biopsy guidance, followed by radical prostatectomy at our institution between 07/2016 and 01/2020. The dominant lesion per patient was selected based on histopathology and correlated to PET/MRI in a multidisciplinary meeting, and quantified using SUV_max for PSMA uptake and ADC_mean for diffusion restriction. PCa growth pattern was classified as expansive (EXP) or infiltrative (INF) according to its properties of forming a tumoral mass or infiltrating diffusely between benign glands by two independent pathologists. Furthermore, the corresponding WHO2016 ISUP tumor grade was evaluated. The t test was used to compare means, Pearson's test for categorical correlation, Cohen's kappa test for interrater agreement, and ROC curve to determine the best cutoff. Sixty-two patients were included (mean PSA 11.7 ± 12.5). The interrater agreement between both pathologists was almost perfect with κ = 0.81. While 25 lesions had an EXP-growth with an ADC_mean of 0.777 ± 0.109, 37 showed an INF-growth with a significantly higher ADC_mean of 1.079 ± 0.262 (p < 0.001). We also observed a significant difference regarding PSMA SUV_max for the EXP-growth (19.2 ± 10.9) versus the INF-growth (9.4 ± 6.2, p < 0.001). Within the lesions encompassing the EXP- or the INF-growth, no significant correlation between the ISUP groups and ADC_mean could be observed (p = 0.982 and p = 0.861, respectively). PCa with INF-growth showed significantly lower SUV_max and higher ADC_mean values compared to PCa with EXP-growth. Within the growth groups, ADC_mean values were independent from ISUP grading.