iSFun: an R package for integrative dimension reduction analysis.

Abstract

In the analysis of high-dimensional omics data, dimension reduction techniques-including principal component analysis (PCA), partial least squares (PLS) and canonical correlation analysis (CCA)-have been extensively used. When there are multiple datasets generated by independent studies with compatible designs, integrative analysis has been developed and shown to outperform meta-analysis, other multidatasets analysis, and individual-data analysis. To facilitate integrative dimension reduction analysis in daily practice, we develop the R package iSFun, which can comprehensively conduct integrative sparse PCA, PLS and CCA, as well as meta-analysis and stacked analysis. The package can conduct analysis under the homogeneity and heterogeneity models and with the magnitude- and sign-based contrasted penalties. As a 'byproduct', this article is the first to develop integrative analysis built on the CCA technique, further expanding the scope of integrative analysis. The package is available at https://CRAN.R-project.org/package=iSFun. Supplementary materials are available at Bioinformatics online.