Lay A TRAP for myeloid cell response in diabetic kidney disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35461612.
- Also identified by DOI 10.1016/j.kint.2022.02.001.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The functions of the renin-angiotensin system are crucial in the progression of diabetic kidney disease. ATRAP is a type 1 angiotensin II receptor-associated protein that negatively regulates intracellular angiotensin II signaling. In this issue, Haruhara et al. revealed that ATRAP deficiency of diabetic mice decreases anti-inflammatory macrophage infiltration and exacerbates albuminuria. The adoptive transfer and tubule-specific depletion of ATRAP highlight the crosstalk between glomerular injury and tubulointerstitial angiotensin II signaling and innate immunity.
Medical subject headings
- Adaptor Proteins, Signal Transducing
- Diabetes Mellitus, Experimental
- Diabetic Nephropathies