Posttreatment Gene Scores Support Histologic and Endoscopic Response Thresholds in Eosinophilic Esophagitis.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 35470295.
- Also identified by DOI 10.14309/ajg.0000000000001802 and PMC identifier 9437112.
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Abstract
The correlation between clinical and molecular treatment response thresholds in eosinophilic esophagitis (EoE) is not well understood. We evaluated posttreatment EoE diagnostic panel gene expression profiles across histologic and endoscopic thresholds (EREFS) in a prospective adult EoE cohort. We observed a strong inverse correlation between posttreatment gene score and eosinophil count (R = -0.66; P < 0.001); biopsies with <15 eos/hpf had higher gene scores (≥425) vs those with ≥15 eos/hpf. Findings for EREFS were similar; EREFS ≤2 was associated with EoE diagnostic panel scores ≥395. Molecular signatures support the use of posttreatment response thresholds <15 eos/hpf and EREFS ≤2 in clinical practice and trials.
Medical subject headings
- Eosinophilic Esophagitis