Advancing natural killer therapies against cancer.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35487189.
- Also identified by DOI 10.1016/j.cell.2022.04.006.
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Abstract
Natural killer (NK)-based therapies against cancer are emerging, but the understanding of NK cell functions needs to be completed to optimize these treatments. In this issue, Pan et al. (2022) show that pro-apoptotic molecules, such as BH3-mimetics, synergize with NK cells to induce mitochondria-driven apoptosis in tumor cells, thereby enhancing the efficacy of NK cell therapies.
Medical subject headings
- Killer Cells, Natural
- Neoplasms