Why "sex as a biological variable" conflicts with precision medicine initiatives.

DiMarco, Marina; Zhao, Helen; Boulicault, Marion; Richardson, Sarah S · Cell Rep Med · 2022

expert_opinion · Level V

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Abstract

Policies that require male-female sex comparisons in all areas of biomedical research conflict with the goal of improving health outcomes through context-sensitive individualization of medical care. Sex, like race, requires a rigorous, contextual approach in precision medicine. A "sex contextualist" approach to gender-inclusive medicine better aligns with this aim.

Medical subject headings