Harnessing the chemokine system to home CAR-T cells into solid tumors.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35492880.
- Also identified by DOI 10.1016/j.xcrm.2022.100543 and PMC identifier 9040186.
- Licence recorded as CC BY-NC-ND.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
CAR-T cell therapy has been heralded as a breakthrough in the field of immunotherapy, but to date, this success has been limited to hematological malignancies. By harnessing the chemokine system and taking into consideration the chemokine expression profile in the tumor microenvironment, CAR-T cells may be homed into tumors to facilitate direct tumor cell cytolysis and overcome a major hurdle in generating effective CAR-T cell responses to solid cancers.
Medical subject headings
- Neoplasms
- Receptors, Antigen, T-Cell