Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35501346.
- Also identified by DOI 10.1038/s41467-022-30082-4 and PMC identifier 9061844.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Thyroid hormones are essential regulators of metabolism, development, and growth. They are formed from pairs of iodinated tyrosine residues within the precursor thyroglobulin (TG), a 660-kDa homodimer of the thyroid gland, by an oxidative coupling reaction. Tyrosine pairs that give rise to thyroid hormones have been assigned within the structure of human TG, but the process of hormone formation is poorly understood. Here we report a ~3.3-Å cryo-EM structure of native bovine TG with nascent thyroid hormone formed at one of the predicted hormonogenic sites. Local structural rearrangements provide insight into mechanisms underlying thyroid hormone formation and stabilization.
Medical subject headings
- Thyroglobulin
- Thyroid Hormones