Atherosclerosis: Recent developments.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35504280.
- Also identified by DOI 10.1016/j.cell.2022.04.004 and PMC identifier 9119695.
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Abstract
Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the molecular, cellular, genetic, and environmental contributions to atherosclerosis, from both individual pathway and systems perspectives. We place an emphasis on recent developments, some of which have yielded unexpected biology, including previously unknown heterogeneity of inflammatory and smooth muscle cells in atherosclerotic lesions, roles for senescence and clonal hematopoiesis, and links to the gut microbiome.
Medical subject headings
- Atherosclerosis
- Gastrointestinal Microbiome