Bacteriophage treatment of disseminated cutaneous Mycobacterium chelonae infection.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 35504908.
- Also identified by DOI 10.1038/s41467-022-29689-4 and PMC identifier 9064978.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Mycobacterium chelonae is a rare cause of chronic disseminated cutaneous infections in immunocompromised patients. Multidrug-resistant M. chelonae infections present a challenge for treatment, and prolonged antimicrobial courses lead to significant toxicities and further antimicrobial resistance. We report a case of refractory cutaneous disseminated M. chelonae infection in a patient with seronegative arthritis on immunotherapy with tofacitinib that was treated with combination antimicrobial, surgical, and single bacteriophage therapy with excellent clinical response. The patient developed neutralizing antibodies against the bacteriophage but continues to have stable improvement of disease with negative biopsies and no evidence of bacterial resistance to the phage.
Medical subject headings
- Bacteriophages
- Mycobacterium Infections, Nontuberculous
- Mycobacterium chelonae
- Skin Diseases, Bacterial