Dihydroquinazolinones as adaptative C(sp³) handles in arylations and alkylations via dual catalytic C-C bond-functionalization.

Abstract

C-C bond forming cross-couplings are convenient technologies for the construction of functional molecules. Consequently, there is continual interest in approaches that can render traditionally inert functionality as cross-coupling partners, included in this are ketones which are widely-available commodity chemicals and easy to install synthetic handles. Herein, we describe a dual catalytic strategy that utilizes dihydroquinazolinones derived from ketone congeners as adaptative one-electron handles for forging C(sp³) architectures via α C-C cleavage with aryl and alkyl bromides. Our approach is achieved by combining the flexibility and modularity of nickel catalysis with the propensity of photoredox events for generating open-shell reaction intermediates. This method is distinguished by its wide scope and broad application profile--including chemical diversification of advanced intermediates--, providing a catalytic technique complementary to existing C(sp³) cross-coupling reactions that operates within the C-C bond-functionalization arena.