PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 35508105.
- Also identified by DOI 10.1016/j.cmet.2022.02.008 and PMC identifier 9531314.
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Abstract
Chen et al. reveal an increase of phosphoglycerate dehydrogenase (PHGDH) mRNA and protein levels in two mouse models and four human cohorts in Alzheimer's disease brains compared to age- and sex-matched control brains. The increase of PHGDH expression in human brain correlates with symptomatic development and disease pathology.
Medical subject headings
- Alzheimer Disease
- Phosphoglycerate Dehydrogenase