Glass-patternable notch-shaped microwave architecture for on-chip spin detection in biological samples.

Oshimi, Keisuke; Nishimura, Yushi; Matsubara, Tsutomu; Tanaka, Masuaki; Shikoh, Eiji; Zhao, Li; Zou, Yajuan; Komatsu, Naoki et al. · Lab Chip · 2022

basic_science · Level V

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Abstract

We report a notch-shaped coplanar microwave waveguide antenna on a glass plate designed for on-chip detection of optically detected magnetic resonance (ODMR) of fluorescent nanodiamonds (NDs). A lithographically patterned thin wire at the center of the notch area in the coplanar waveguide realizes a millimeter-scale ODMR detection area (1.5 × 2.0 mm<sup>2</sup>) and gigahertz-broadband characteristics with low reflection (∼8%). The ODMR signal intensity in the detection area is quantitatively predictable by numerical simulation. Using this chip device, we demonstrate a uniform ODMR signal intensity over the detection area for cells, tissue, and worms. The present demonstration of a chip-based microwave architecture will enable scalable chip integration of ODMR-based quantum sensing technology into various bioassay platforms.

Medical subject headings