Emergence of Dalbavancin, Vancomycin, and Daptomycin Nonsusceptible Staphylococcus aureus in a Patient Treated With Dalbavancin: Case Report and Isolate Characterization.
case_report · Level V
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- Record sourced from PubMed, PMID 35510938.
- Also identified by DOI 10.1093/cid/ciac341 and PMC identifier 10200325.
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Abstract
A patient with end-stage renal disease received 2 doses of dalbavancin for methicillin-resistant Staphylococcus aureus (MRSA) arteriovenous fistula infection and presented 5 weeks later with infective endocarditis secondary to vancomycin, daptomycin, and dalbavancin nonsusceptible MRSA. Resistance was associated with walK and scrA mutations, reduced long-chain lipid content, and reduced membrane fluidity.
Medical subject headings
- Daptomycin
- Methicillin-Resistant Staphylococcus aureus
- Staphylococcal Infections