Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35512094.
- Also identified by DOI 10.1073/pnas.2202439119 and PMC identifier 9171807.
- Licence recorded as CC BY-NC-ND.
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Abstract
SignificanceMesothelin (MSLN) is a cell-surface protein that is a popular target for antibody-based therapies. We have identified shed MSLN as a major obstacle to successful antibody therapies and prepared a monoclonal antibody that inhibits shedding and makes very active CAR T cells whose activity is not blocked by shed MSLN and merits further preclinical development.
Medical subject headings
- Receptors, Chimeric Antigen