All About That Ras: Novel Fusion Drives Ras Pathway Activation in Lung Cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35512219.
- Also identified by DOI 10.1158/1078-0432.CCR-22-0736 and PMC identifier 9451010.
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Abstract
Lung cancers in never- and light-smokers often harbor targetable oncogenic mutations in Ras pathway genes. Here, a novel OCLN-RASGRF1 fusion is identified in an otherwise Ras wild-type lung tumor. Studying this and other RASGRF1 fusions, the authors show that these fusions lead to malignant phenotypes that can be reversed by MEK inhibition. See related article by Hunihan et al., p. 3091.
Medical subject headings
- Lung Neoplasms
- ras-GRF1