iPSC model of congenital heart disease predicts disease outcome.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35523134.
- Also identified by DOI 10.1016/j.stem.2022.04.010.
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Abstract
In this issue of Cell Stem Cell, Xu et al. demonstrate that induced pluripotent stem cell-derived cardiomyocytes from patients with hypoplastic left heart syndrome exhibit mitochondrial dysfunction and can be used for disease modeling. In addition, they show the potential to predict future heart failure and develop therapies.
Medical subject headings
- Heart Defects, Congenital
- Heart Failure
- Induced Pluripotent Stem Cells