SimSCSnTree: a simulator of single-cell DNA sequencing data.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35561189.
- Also identified by DOI 10.1093/bioinformatics/btac169.
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Abstract
We report on a new single-cell DNA sequence simulator, SimSCSnTree, which generates an evolutionary tree of cells and evolves single nucleotide variants (SNVs) and copy number aberrations (CNAs) along its branches. Data generated by the simulator can be used to benchmark tools for single-cell genomic analyses, particularly in cancer where SNVs and CNAs are ubiquitous. SimSCSnTree is now on BioConda and also is freely available for download at https://github.com/compbiofan/SimSCSnTree.git with detailed documentation.
Medical subject headings
- Genome
- Genomics