CD70 CAR T cells in AML: Form follows function.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35584621.
- Also identified by DOI 10.1016/j.xcrm.2022.100639 and PMC identifier 9133448.
- Licence recorded as CC BY-NC-ND.
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Abstract
Using a multimodal approach toward developing a new CD70-targeted Chimeric antigen receptor (CAR) T cell in acute myeloid leukemia, Leick et al.<sup>1</sup> report on their synergetic strategy, which incorporates both CAR T cell construct modifications with enhancement of leukemia antigen expression to improve CAR T cell functionality.
Medical subject headings
- CD27 Ligand
- Immunotherapy, Adoptive
- Leukemia, Myeloid, Acute
- Receptors, Chimeric Antigen