Higher In Vivo Fecal Concentrations of Clostridioides difficile Toxins A and B in Patients With North American Pulsed-Field Gel Electrophoresis Type 1/Ribotype 027 Strain Infection.

Alonso, Carolyn D; Pollock, Nira R; Garey, Kevin W; Gonzales-Luna, Anne J; Williams, David N; Daugherty, Kaitlyn; Cuddemi, Christine; Villafuerte-Gálvez, Javier et al. · Clin Infect Dis · 2022

cross_sectional · Level IV

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Abstract

Ultrasensitive, quantitative Clostridioides difficile stool toxin measurement demonstrated significantly higher concentrations of toxins A and B in patients infected with the North American pulsed-field gel electrophoresis type 1/ribotype 027 (NAP-1/027) strain compared with other strains, providing in vivo confirmation of the in vitro association between NAP-1/027 and elevated toxin production.

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