The potential of polygenic scores to improve cost and efficiency of clinical trials.
Where this comes from
- Record sourced from PubMed, PMID 35614072.
- Also identified by DOI 10.1038/s41467-022-30675-z and PMC identifier 9132885.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Polygenic scores can identify individuals with high disease risk based on inborn DNA variation. We explore their potential to enrich clinical trials by identifying individuals based on higher risk of disease (‘prognostic enrichment’), or increased probability of benefit (‘predictive enrichment’).
Medical subject headings
- Clinical Trials as Topic
- Multifactorial Inheritance