Generation of Novel Severe Acute Respiratory Syndrome Coronavirus 2 Variants on the B.1.1.7 Lineage in 3 Patients With Advanced Human Immunodeficiency Virus-1 Disease.

Riddell, Anna C; Kele, Beatrix; Harris, Kathryn; Bible, Jon; Murphy, Maurice; Dakshina, Subathira; Storey, Nathaniel; Owoyemi, Dola et al. · Clin Infect Dis · 2022

case_series · Level IV

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Abstract

The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is of public health concern in case of vaccine escape. Described are 3 patients with advanced human immunodeficiency virus (HIV)-1 and chronic SARS-CoV-2 infection in whom there is evidence of selection and persistence of novel mutations that are associated with increased transmissibility and immune escape.

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