Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp<sup>2</sup>)-H bonds.
basic_science · Level V
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- Record sourced from PubMed, PMID 35618702.
- Also identified by DOI 10.1038/s41467-022-30367-8 and PMC identifier 9135730.
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Abstract
Hydroarylation of alkynes with unactivated C(sp<sup>2</sup>)-H bonds via chelated C-H metalation mainly occurs at γ-position to the coordinating atom of directing groups via stable 5-membered metallacycles, while β-C(sp<sup>2</sup>)-H bond-involved hydroarylation has been a formidable challenge. Herein, we used a phosphine oxide-ligated Ni-Al bimetallic catalyst to enable β-C-H bond-involved hydroarylations of alkynes via a rare 7-membered nickelacycle.