MicroRNAs as therapeutic targets in cardiovascular disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35642640.
- Also identified by DOI 10.1172/JCI159179 and PMC identifier 9151703.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The discovery of microRNAs and their role in diseases was a breakthrough that inspired research into microRNAs as drug targets. Cardiovascular diseases are an area in which limitations of conventional pharmacotherapy are highly apparent and where microRNA-based drugs have appreciably progressed into preclinical and clinical testing. In this Review, we summarize the current state of microRNAs as therapeutic targets in the cardiovascular system. We report recent advances in the identification and characterization of microRNAs, their manipulation and clinical translation, and discuss challenges and perspectives toward clinical application.
Medical subject headings
- Cardiovascular Diseases
- MicroRNAs