A human embryo model cracks symmetry breaking.

Boroviak, Thorsten E · Cell Stem Cell · 2022

editorial · Level V

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Abstract

In this issue of Cell Stem Cell, Simunovic et al. (2022) establish embryoids by combining embryonic and extraembryonic components derived from human pluripotent stem cells. The embryoids resemble human embryos cultured to post-implantation stages in vitro with regard to morphology, symmetry breaking, and the formation of primitive streak-like cell types.

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