Multicellular dynamics of zonal liver regeneration mapped in space and time.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 35659871.
- Also identified by DOI 10.1016/j.stem.2022.05.008.
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Abstract
In this issue, Ben-Moshe et al. (2022) use spatiotemporally resolved single-cell and spatial transcriptomic profiling to dissect the multicellular dynamics enabling zonal liver regeneration. They highlight how pan-zonal compensatory hepatocyte proliferation, transient reprogramming of peri-injury hepatocytes, and concerted zonated action of different liver cell types orchestrate the healing process.
Medical subject headings
- Hepatocytes
- Liver Regeneration