Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35662394.
- Also identified by DOI 10.7554/eLife.64742 and PMC identifier 9170246.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
LRRTMs are postsynaptic cell adhesion proteins that have region-restricted expression in the brain. To determine their role in the molecular organization of synapses in vivo, we studied synapse development and plasticity in hippocampal neuronal circuits in mice lacking both <i>Lrrtm1</i> and <i>Lrrtm2</i>. We found that LRRTM1 and LRRTM2 regulate the density and morphological integrity of excitatory synapses on CA1 pyramidal neurons in the developing brain but are not essential for these roles in the mature circuit. Further, they are required for long-term-potentiation in the CA3-CA1 pathway and the dentate gyrus, and for enduring fear memory in both the developing and mature brain. Our data show that LRRTM1 and LRRTM2 regulate synapse development and function in a cell-type and developmental-stage-specific manner, and thereby contribute to the fine-tuning of hippocampal circuit connectivity and plasticity.
Medical subject headings
- Membrane Proteins
- Nerve Tissue Proteins
- Neural Cell Adhesion Molecules