Control of Epstein-Barr Virus (EBV) in the Oral Cavity Is Associated With Persistence of Oral Human Papillomavirus (HPV)16/18 Among Men From the HPV Infection in Men Study.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 35679351.
- Also identified by DOI 10.1093/infdis/jiac223 and PMC identifier 10202421.
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Abstract
Human papillomavirus (HPV)-related oropharyngeal cancer (OPC) incidence is increasing among men. Biomarkers that can identify oral HPV16/18 infections likely to persist, the obligate precursor for HPV-OPC, are needed. We assessed the association between oral Epstein-Barr virus (EBV) and oral HPV16/18 persistence among 63 men in the HPV Infection in Men Study who tested positive for HPV16/18 at the baseline visit. Control of oral coinfections, including EBV, could serve as a biomarker of immune competence and the ability to control oral HPV. Detection of oral EBV was significantly associated with oral HPV16/18 ≥12-month persistence. Detection of oral EBV deserves evaluation as a biomarker for oral HPV persistence and HPV-related OPC.
Medical subject headings
- Papillomavirus Infections
- Epstein-Barr Virus Infections
- Oropharyngeal Neoplasms
- Mouth Diseases