An Active Learning Framework Improves Tumor Variant Interpretation.

Blee, Alexandra M; Li, Bian; Pecen, Turner; Meiler, Jens; Nagel, Zachary D; Capra, John A; Chazin, Walter J · Cancer Res · 2022

basic_science · Level V

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Abstract

A novel machine learning approach predicts the impact of tumor mutations on cellular phenotypes, overcomes limited training data, minimizes costly functional validation, and advances efforts to implement cancer precision medicine.

Medical subject headings