A zinc chaperone mediates the flow of an inorganic commodity to an important cellular client.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35688131.
- Also identified by DOI 10.1016/j.cell.2022.05.012.
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Abstract
Zinc is an essential element in living organisms, yet little is known about how cells ensure that zinc is allocated to the correct metalloproteins. Papers in Cell and Cell Reports demonstrate that the ZNG1 family of GTPases have metallochaperone functions: they directly transfer zinc to, and thereby activate, methionine aminopeptidases that are crucial for protein modification during or after translation.
Medical subject headings
- Metalloproteins
- Zinc