SPEAR: Systematic ProtEin AnnotatoR.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 35695776.
- Also identified by DOI 10.1093/bioinformatics/btac391 and PMC identifier 9344845.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We present Systematic ProtEin AnnotatoR (SPEAR), a lightweight and rapid SARS-CoV-2 variant annotation and scoring tool, for identifying mutations contributing to potential immune escape and transmissibility (ACE2 binding) at point of sequencing. SPEAR can be used in the field to evaluate genomic surveillance results in real time and features a powerful interactive data visualization report. SPEAR and documentation are freely available on GitHub: https://github.com/m-crown/SPEAR and are implemented in Python and installable via Conda environment. Supplementary data are available at Bioinformatics online.
Medical subject headings
- SARS-CoV-2
- COVID-19