Rebound Phenomenon After Nirmatrelvir/Ritonavir Treatment of Coronavirus Disease 2019 (COVID-19) in High-Risk Persons.

Ranganath, Nischal; O'Horo, John C; Challener, Douglas W; Tulledge-Scheitel, Sidna M; Pike, Marsha L; O'Brien, Michael; Razonable, Raymund R; Shah, Aditya · Clin Infect Dis · 2023

prospective_cohort · Level II

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Abstract

In a cohort of 483 high-risk patients treated with nirmatrelvir/ritonavir for COVID-19, 2 patients (0.4%) required hospitalization by day 30. Four patients (0.8%) experienced rebound of symptoms, which were generally mild, at a median of 9 days after treatment, and all resolved without additional COVID-19-directed therapy.

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