Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35710627.
- Also identified by DOI 10.1038/s41536-022-00226-7 and PMC identifier 9203768.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs.