68 Ga-FAPI-46 and 18 F-FDG in Advanced Metastatic Pancreatic Cancer.

Kaghazchi, Fatemeh; Divband, Ghasemali; Amini, Hamidreza; Adinehpour, Zohreh; Akbarian Aghdam, Ramin · Clin Nucl Med · 2022

case_report · Level V

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Abstract

Recently imaging with new PET radiotracers that act as fibroblast activation protein inhibitors (FAPIs) showed promising results in oncology and even nononcology imaging. Here we report a case of advanced pancreatic adenocarcinoma, imaged with both 18 F-FDG and 68 Ga-FAPI-46 PET/CT scans. The result indicated that imaging with 68 Ga-FAPI-46 showed significant improvement in detection of metastases as well as local malignancy recurrence. Moreover, the intensity and SUVs of the lesions were higher in 68 Ga-FAPI-46 scan compared with 18 F-FDG.

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