Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse.

Ntinginya, Nyanda Elias; Bakuli, Abhishek; Mapamba, Daniel; Sabiiti, Wilber; Kibiki, Gibson; Minja, Lilian Tina; Kuchaka, Davis; Reither, Klaus et al. · Clin Infect Dis · 2023

prospective_cohort · Level II

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Abstract

Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8.

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