Omicron Breakthrough Infection After Heterologous Prime-Boost Vaccination Induces a Vigorous Antibody Response.

Varese, Augusto; Mazzitelli, Bianca; Erra Díaz, Fernando; Kjolhede, María Victoria; Ojeda, Diego; Vellicce, Alejandra; Arto, Penélope; Cicero, Carla et al. · J Infect Dis · 2022

case_series · Level IV

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Abstract

Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variant is usually asymptomatic or mild and appears to be poorly immunogenic at least in unvaccinated individuals. Here, we found that health care workers vaccinated with 2 doses of Sputnik V and a booster dose of ChAdOx1 mount a vigorous neutralizing-antibody response after Omicron breakthrough infection.

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