The healing of bone defects by cell-free and stem cell-seeded 3D-printed PLA tissue-engineered scaffolds.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35725606.
- Also identified by DOI 10.1186/s13018-022-03213-2 and PMC identifier 9208215.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed that both cell-free and stem cell-seeded scaffolds exhibited superb healing compared with the empty defect controls, and new bone and connective tissues were formed in the healing site after 8 and 12 weeks, postoperatively. The higher filled area, bone formation and bone maturation were observed after 12 weeks, particularly for PLA + Cell scaffolds.
Medical subject headings
- Bone Regeneration
- Tissue Scaffolds