CDC20 regulates sensitivity to chemotherapy and radiation in glioblastoma stem cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 35737702.
- Also identified by DOI 10.1371/journal.pone.0270251 and PMC identifier 9223386.
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Abstract
Glioblastoma stem cells (GSCs) are an important subpopulation in glioblastoma, implicated in tumor growth, tumor recurrence, and radiation resistance. Understanding the cellular mechanisms for chemo- and radiation resistance could lead to the development of new therapeutic strategies. Here, we demonstrate that CDC20 promotes resistance to chemotherapy and radiation therapy. CDC20 knockdown does not increase TMZ- and radiation-induced DNA damage, or alter DNA damage repair, but rather promotes cell death through accumulation of the pro-apoptotic protein, Bim. Our results identify a CDC20 signaling pathway that regulates chemo- and radiosensitivity in GSCs, with the potential for CDC20-targeted therapeutic strategies in the treatment of glioblastoma.
Medical subject headings
- Brain Neoplasms
- Glioblastoma