The Central Role of mTORC1 in Amino Acid Sensing.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 35749594.
- Also identified by DOI 10.1158/0008-5472.CAN-21-4403.
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Abstract
The mTOR is a master regulator of cell growth that controls cell homeostasis in response to nutrients, growth factors, and other environmental cues. Recent studies have emphasized the importance of lysosomes as a hub for nutrient sensing, especially amino acid sensing by mTORC1. This review highlights recent advances in understanding the amino acid-mTORC1 signaling axis and the role of mTORC1 in cancer.
Medical subject headings
- Amino Acids
- Lysosomes